Overview

Evaluation of Renal Protection Of Dexmedetomidine Versus Midazolam As a Sedative For Septic Patients In Intensive Care Unit

Status:
Recruiting

Trial end date:
2023-12-20

Target enrollment:
0

Participant gender:
All

Summary

Evaluation of Renal Protection Of Dexmedetomidine Versus Midazolam As a Sedative For Septic Patients In Intensive Care Unit

Phase:

Phase 1

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Minia University

Treatments:

Dexmedetomidine
Midazolam

Criteria

Inclusion Criteria:

- Age (18-80) years old. sex:both male and female.

- intubated and mechanically ventilated patients.

Exclusion Criteria:

- 1.Patient's relatives refusal. 2. burns as admitting diagnoses. 3.patients with any
renal pathology(such as chronic glomerulonephritis, pyelonephritis and diabetic
nephropathy).

4. pregnancy or lactation. 5. serious central nervous system pathology (acute stroke,
uncontrolled seizures, severe dementia).

6. acute hepatitis or severe liver disease (Child-Pugh class C). 7. unstable angina or
acute myocardial infarction, left ventricular ejection fraction less than 30%, heart
rate less than 50/min, second- or third-degree heart block, or systolic blood pressure
less than 90 mm Hg despite continuous infusions of 2 vasopressors before the start of
study drug infusion.