Evaluation of Renal Sodium Excretion After Salt Loading in Heart Failure With Preserved Ejection Fraction
Status:
Completed
Trial end date:
2020-02-20
Target enrollment:
Participant gender:
Summary
Heart failure (HF) affects 2-3% of the population, and is characterized by impaired sodium
balance which results in fluid overload. Ejection fraction, a measure of systolic function,
is reduced in only about half of all HF patients. Incidence of heart failure with preserved
ejection fraction (HFpEF) has increased in the last 20 years making it a growing public
health problem. Currently, most patients admitted to the hospital with heart failure have
preserved rather than reduced ejection fractions. However, to date it remains unknown why
patients with HFpEF retain salt and water. The hypothesis is that patients with clinical
HFpEF have an impaired renal response to salt loading, intravascular expansion and diuretics.
Characterization of the salt and water excretory renal response to intravascular salt, fluid
and diuretic load in patients with HFpEF will provide insight into the pathophysiology of
HFpEF, and may help in the development of novel strategies to target renal sodium handling in
patients with HFpEF. This characterization is the primary objective of this pilot project.
Phase:
Early Phase 1
Details
Lead Sponsor:
Adhish Agarwal
Collaborator:
University of Utah Center for Clinical and Translational Science