Evaluation of Simplified Antiretroviral Treatment Strategies in HIV Infected Children Treated by Antiretroviral (ARV) Before One Year of Age

• Status: Completed
• Trial end date: 2015-04-01

Summary

The MONOD trial aim to evaluate the implementation of early antiretroviral treatment strategies in HIV-infected infants and assess the feasibility and efficacy of simplifying the initial proposed regimen after a successful one year treatment. The initial treatment is AZT-3TC-LPV/r twice a day. After one year, the children will be randomized in one of the following : arm 1-reference AZT-3TC-LPV/r twice daily; arm 2-simplified ABC-3TC-EFV once daily.

The perspective of this project is to identify antiretroviral strategies to improve treatment access and adherence for children in sub-saharian Africa.

• Phase: Phase 2/Phase 3

Details

• Lead Sponsor: ANRS, Emerging Infectious Diseases; French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)
• Collaborators: European and Developing Countries Clinical Trials Partnership (EDCTP); Institut de Sante Publique, d'Epidémiologie et de Développement; Institut National de la Santé Et de la Recherche Médicale, France; Ministry of Foreign Affairs, Luxembourg; Ministry of Health, Rwanda; Programme national,ANRS,Coopération française-Côte d'Ivoire (PAC-CI), Côte d'Ivoire; Programme PAC-CI, Site ANRS-MIE de Côte d'Ivoire; Public Research Centre Health, Luxembourg; Queen Fabiola Children's University Hospital; Université Montpellier; University of Bordeaux; University of Ouagadougou, Burkina Faso; University of Paris 5 - Rene Descartes
• Treatments: Lamivudine