Evaluation of Smectite Effect As A Food Thickener On Gastroesophageal Reflux Disease In Neonates Using Combined Esophageal Multichannel Intraluminal Impedance

• Status: Completed
• Trial end date: 2021-03-01
• Target enrollment: 0
• Participant gender: All

Summary

study of diagnosis of GERD in neonates by MII-PH with trial of smectite for treatment

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams Maternity Hospital

Criteria

Inclusion Criteria:

• • Newborns free of any congenital anomalies or inborn errors of metabolism

• Infants had signs of reflux like:

1. Typical or atypical crying and/or irritability

2. Apparent life-threatening event

3. Poor appetite; weight loss or poor growth (failure to thrive)

4. Vomiting

5. Bronchopulmonary dysplasia

6. Wheezing, stridor

7. Recurrent pneumonitis

8. Sandifer syndrome (ie, posturing with opisthotonus or torticollis)

Exclusion Criteria:

• • Newborns with GIT anomalies as trans-esophageal fistula, hiatus hernia and other GIT anomalies causing reflux.

• Patients with Hirshsprung disease or delayed passage of meconium.

• History of NEC in the baby.