Evaluation of Surgically Resected Colorectal Adenomas and Carcinomas After 7 Days Pretreatment With Celecoxib
Status:
Completed
Trial end date:
2008-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to assess how effective celecoxib is in limiting production of a
hormone, prostaglandin, in the subject's body. It is felt that this hormone is involved in
the evolution of pre-cancerous growths in the colon to cancerous stage or in the progression
of an existing cancer. To answer this question, some subjects are given the new
investigational drug, and other subjects a placebo. A placebo is a capsule that contains
inactive ingredients. Only by comparing the response of two subject groups, one receiving
placebo (inactive), and one receiving celecoxib (active), will we be able to know whether or
not celecoxib actually works. The outcome we are assessing is the hormone activity before and
after celecoxib is given.