Evaluation of TNF-α Blockade Effect in Patients With Severe Cutaneous Adverse Drug Reactions
Status:
Completed
Trial end date:
2015-05-01
Target enrollment:
Participant gender:
Summary
Severe skin adverse drug reactions can result in death. Toxic epidermal necrolysis (TEN) has
the highest mortality (30-35%); Stevens-Johnson syndrome and transitional forms correspond to
the same syndrome, but with less extensive skin detachment and a lower mortality (5-15%).
Hypersensitivity syndrome, sometimes called Drug Reaction with Eosinophilia and Systemic
Symptoms (DRESS), has a mortality rate evaluated at about 10%. The aims of this project are
(1) to compare the effect of treatment between systemic steroid and anti-TNF-α. Including
skin healing time, beginning of re-epithelialization time, internal organ recovery time,
mortality rate, adverse events and (2) to investigate the molecular mechanism of severe
cutaneous adverse reaction after anti-TNF-α treatment.