Evaluation of The Effect of Loratadine Versus Diosmin/Hesperidin Combination on Vinca Alkaloids Induced Neuropathy

• Status: Not yet recruiting
• Trial end date: 2023-12-30
• Target enrollment: 0
• Participant gender: All

Summary

All vinca alkaloids causes neuropathy. The incidence of peripheral neuropathy is 30 %-40 % in patients treated with vincristine. The incidence of long term neurological adverse events from vinblastine ranged from 50% to 97%. In this study, the investigators will study the effect of using either loratadine or diosmin 450mg/ hesperidin 50 mg combination on neuropathy caused by Vinca alkaloids therapy. This study is a prospective, controlled, randomized, interventional and open-label clinical trial.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Loratadine

Criteria

Inclusion Criteria:

1. Patients prescribed vincristine or vinblastine according to standard protocols.

2. Adult patients older than18 years.

3. Patients willing to participate in the study and sign the informed consent.

4. Adequate bone barrow function (platelet count> 150 *103per microliter, absolute neutrophil count> 500 per microliter)

5. Eastern cooperative oncology group (ECOG) performance status Grade 0-2

Exclusion Criteria:

1. Hypersensitivity or contraindication to loratadine, hesperidin or diosmin combination or any component of the formulation.

2. Pre-existence or history of peripheral neuropathy due to a cause different from Vinca alkaloids induced neuropathy.

3. Receiving any other medication known to cause neuropathy.

4. Receiving medications with drug interaction grade X with Loratadine as Thalidomide, Tiotropium or Orphenadrine.

5. Women of childbearing potential not using an effective contraceptive method.

6. Pregnancy or breastfeeding.

7. Inability to understand patients' information and informed consent form.

8. Severe hepatic impairment.