Overview

Evaluation of The Effect of Rutin and Vitamin C on the Oxidative Stress in Hemodialysis Patients

Status:
Recruiting

Trial end date:
2022-02-01

Target enrollment:
0

Participant gender:
All

Summary

The aim of the study is to evaluate the effect of rutin and vitamin C on selected oxidative stress and inflammatory markrers. Patients will be recruited according to the inclusion and exclusion criteria and will be divided into 3 groups, Group 1: Patients will administer a combination of Vitamin C and Rutin (RUTA C 60 tablets) in a dose of 2 tablets 3 times daily for 4 months in addition to their standard therapy, Group 2: will administer vitamin C 500mg hard gelatin capsules (twice daily) in addition to their standard therapy for a period of 4 months, Group3 (Control group) will administer the standard therapy. Blood samples will be withdrawn for measurement of; MDA, TNF-α ,GSH-PX, C-RP levels and ESR.

Phase:

Phase 3

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Ain Shams University

Criteria

Inclusion Criteria:

- Age of patients > 18 year old.

- hemodialysis in the last 3 months or longer.

- hemodialysis frequency 3 times per week or more.

Exclusion Criteria:

1. Treatment with antioxidant agents [such as vitamin C and E during the 2 preceding
months prior to the study.

2. Active liver disease

3. pregnant patients or patients planning pregnancy.

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