Evaluation of Time Interval Between Ovulation Trigger With Triptorelin Acetate and Oocyte Retrieval

• Status: Completed
• Trial end date: 2018-02-02
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of this study is to determine what is the best time interval between GnRH agonist (triptorelin acetate) ovulation induction allowing for the higher number of mature oocytes (MII) collected in IVF cycles.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Instituto de Investigacion Sanitaria La Fe
• Treatments: Triptorelin Pamoate

Criteria

Inclusion Criteria:

• Signed informed consent prior to carry out any procedure associated with the clinical trial.

• Women between 18 and 37 years of age at the time of randomization (both ages included).

Basal serum levels of FSH <10 mIU /ml.

• Serum AMH > 5 to <45 pmol / l.

• Antral follicle count > 6 and < 24.

• Vaginal ultrasound documenting correct visualization of both ovaries and the absence of significant ovarian pathology.

• Short stimulation protocol with GnRH antagonist and conventional dose for ovarian stimulation with 225-300 UI of rhFSH.

• Number of follicles ≥ 16 mm > 5 on the ovulation induction day.

Exclusion Criteria:

• Presence of severe endometriosis (Grade III-IV).

• Absence of one ovary due to previous surgery.

• Presence of significant uterine pathology (submucous myomas, endometrial polyp, malformations..)

• Diagnosis of polycystic ovary syndrome (defined according to the Rotterdam criteria).

• History of previous poor response to conventional ovarian stimulation protocols (< 3 MII oocytes or canceled cycle)

• Severe male factor ( TMS< 1 million).

• Participation in another RCT within the past one year.