Evaluation of Tumour Growth and Oncological Treatment in Patients With CRLM Using Zebra Fish Embryo Model
Status:
Recruiting
Trial end date:
2025-03-14
Target enrollment:
Participant gender:
Summary
In order to improve and individualize cancer treatment, personalized treatment needs to be
developed much further. Liver metastasizing colorectal cancer is treated with a combination
of oncological and surgical interventions. The selection of chemotherapy is today mainly done
according to best guess. Today only a small fraction of oncological treatment may be known to
be effective in a person before treatment start, most often it is trial and error. A fast
reliable system for looking at response to different treatments in each unique patient is
much needed and would, if successful, completely change the way we give oncological treatment
today. Patient's tumor tissue will be evaluated with use of zebrafish embryo avatars to
evaluate tumour growth and response to different combinations of chemotherapy. If successful
interventional studies are planned.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
University Hospital, Linkoeping
Collaborators:
Medical Research Council of Southeast Sweden Sahlgrenska University Hospital, Sweden