Evaluation of a New Method for Instilling Eye Drops

• Status: Completed
• Trial end date: 2018-01-07
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this project is to demonstrate that there is a new easier method to instill eye drops in ones own eye that is as effective as applying a drop directly to their open eye. The benefits of this new method include better medication compliance and reduced patient anxiety from instilling their eye drops. This secondary benefit should remove the "approach-avoidance response" that prompts some patients to delay or give-up on instilling their drops just to avoid the angst and frustration produced by the challenge.

The new method involves the patient instilling the eye drop onto their closed eyelid and then blinking the eye drop into their eye. We aim to show that this method has a similar therapeutic effect as the routine administration of an eye drop to an open eye.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Waterloo
• Treatments: Maleic acid; Ophthalmic Solutions; Timolol

Criteria

Aim #1:

Inclusion Criteria:

• both male and female participants are being studied

• minimum age of 21 and maximum age of 80

• healthy volunteers with no previous history of eye disease

Exclusion Criteria:

• no medical conditions representing contraindications to use of topical beta-blocker.

• subject must not have any active inflammatory diseases of the eye, or have a diagnosis of any form of glaucoma

Aim #2:

Inclusion Criteria:

• both male and female participants are being studied

• minimum age of 21 and maximum age of 80

• subjects have been diagnosed with primary open angle glaucoma and are stable on monotherapy

Exclusion Criteria:

• Subjects must have no other ocular disease, or a history of prior ocular trauma, beyond minor corneal abrasion or removal of a superficial corneal foreign body.