Evaluation of a Subcutaneous Progestogen Implants in the Medical Management of Painful Endometriosis
Status:
Terminated
Trial end date:
2019-10-10
Target enrollment:
Participant gender:
Summary
Endometriosis is a chronic relapsing disease characterized by the presence and proliferation
of endometrial glands and stroma outside the uterus. This is a serious disease, widespread,
difficult to live with for the patients, but also difficult to treat for practitioners who
take care of these patients. It affects 1.6% of the general population, but its incidence is
10 times higher (up 40%) in patients with infertility. It occurs mainly by complex chronic
pelvic pain and a negative influence on fertility.
It is a disease whose complexity can be explained to four levels. Firstly, through its
extremely polymorphic character with intraperitoneal superficial forms, ovarian forms and
deep sub-peritoneal forms.
Secondly by the plurality of the main symptoms which are individually non-specific and the
frequency and / or intensity is not correlated with the severity of the disease. This
non-specificity of symptoms partially explains the long lead misdiagnosis, which vary by 5 to
11 years.
Thirdly, by its prevalence which seems very high and largely underestimated. If its precise
estimate in the general population is so complicated, it seems very high in many studies of
patients supported surgically for gynecological reasons. These very large prevalence figures
are observed when some consultations support the hypothesis of a widespread and probably
insufficiently evaluated disease.
Lately by its management, insufficiently amended, for which there is currently only a few
scientifically supported recommendations.
Chronic pain caused by the disease associated with altered sexuality to a loss of fertility
significantly impacts the quality of life of patients.