Overview
Evaluation of the Cellular Pharmacology of Tenofovir and Emtricitabine According to HIV Infection Status
Status:
Completed
Completed
Trial end date:
2014-04-01
2014-04-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
Tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) are two antiretroviral medications used for the treatment and prevention of HIV/AIDS. This study will examine how these medications are processed in the body of people who are HIV-infected, as well as in people who are HIV-uninfected.Phase:
Phase 1Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)Treatments:
EfavirenzEmtricitabine
Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
Tenofovir
Criteria
Inclusion Criteria for HIV-Uninfected Participants:- Ability to provide informed consent
- Ability to comply with the study procedures
Exclusion Criteria for HIV-Uninfected Participants:
- Positive screening test for HIV infection
- Positive screening test for hepatitis B (HBV) infection
- Pregnant or planning to become pregnant in the 3 months after study entry
- Breastfeeding
- If sexually active and fertile (no tubal ligation or hysterectomy), refusal to use two
forms of birth control (e.g., condom and hormonal birth control) during the 60-day
study
- Estimated glomerular filtration rate (GFR) less than 60 mL/min/1.73 m^2 by the
Modification of Diet in Renal Disease (MDRD) method
- Albuminuria (greater than 30 mg urine albumin per g of urine creatinine)
- Blood donation within 56 days of the screening visit
- Any grade I or higher abnormality in hemoglobin, platelets, serum phosphorous, and
lipase on the screening visit; grade I abnormalities in other labs will be evaluated
on a case by case basis (using DAIDS criteria)
- Any greater than grade I abnormality in screening laboratory tests (using DAIDS
grading criteria)
- Medical history of chronic uncontrolled high blood pressure equal to or above 140/90
mm Hg
- Use of any investigational medication in the 30 days before study entry
- Daily anticoagulant therapy (daily aspirin or non-steroidal anti-inflammatory drugs
[NSAIDs] will be allowed if discontinued for 1 week prior to the rectal biopsy)
- Any nephrotoxic concomitant medication (e.g., aminoglycosides, cyclosporine,
cidofovir, foscarnet, amphotericin B)
- Active recreational drug or alcohol abuse
- Any concomitant medication (or herbal product) that, in the opinion of the
investigators, would interfere with the study outcomes (acceptable medications include
acetaminophen, occasional ibuprofen/NSAID, vitamins, and birth control pills)
- History of pathologic bone fractures
- Any chronic or acute medical condition that, in the opinion of the investigator, would
interfere with study conditions, such as cancer, heart disease, or diabetes
- Body weight under 110 pounds
Inclusion Criteria for HIV-Infected Participants:
- HIV-infected adults (HIV documented in medical record or by the primary clinician)
- Clinician/participant plan to initiate TDF/FTC/EFV therapy and agree to separate
TDF/FTC and EFV prescriptions for the initial 30 days of the study
- Ability to provide informed consent
- Ability to comply with the study procedures
Exclusion Criteria for HIV-Infected Participants:
- Antiretroviral therapy in the preceding 6 months
- Pregnant or planning to become pregnant in the 3 months after study entry
- Breastfeeding
- If sexually active and fertile (no tubal ligation or hysterectomy), refusal to use two
forms of birth control (e.g., condom and hormonal birth control) during the 60-day
study
- Estimated GFR less than 60 mL/min/1.73 m^2 by the MDRD method
- Albuminuria (greater than 30 mg urine albumin per g of urine creatinine)
- Greater than a grade II abnormality in hemoglobin or platelets. Greater than a grade
II abnormality in other clinical chemistry or hematology tests that, in the opinion of
the investigators (principal investigator, study coordinator, and study physician) and
primary clinician, would preclude participation in the study. DAIDS grading criteria
will be used.
- Use of any investigational medication in the 30 days before study entry
- Daily anticoagulant therapy (daily aspirin or NSAIDs will be allowed if discontinued
for 1 week prior to the rectal biopsy)
- Any nephrotoxic concomitant medication (e.g., aminoglycosides, cyclosporine,
cidofovir, foscarnet, amphotericin B)
- Any concomitant medication (or herbal product) that, in the opinion of the
investigators, would interfere with the study outcomes (acceptable medications include
acetaminophen, occasional ibuprofen/NSAID, vitamins, and birth control pills)
- Any chronic or acute medical condition that, in the opinion of the investigator, could
lead to emergent health complications, or could interfere with the participant's
ability to follow study procedures
- Body weight under 110 pounds