Evaluation of the Early Use of Norepinephrine in Major Abdominal Surgery on Postoperative Organ Dysfunction
Status:
Recruiting
Trial end date:
2025-04-01
Target enrollment:
Participant gender:
Summary
Hemodynamic instability is frequent during surgery and intraoperative hypotension is
associated with excess morbidity and excess mortality in high-risk patients. In major
abdominal surgery the incidence of intraoperative hypotension remains high.
For the past few years, some teams have proposed evaluating norepinephrine as a first-line
drug in the presence of hypotension or even before hypotension occurs Thus in obstetrics, the
preventive use of norepinephrine for cesareans performed under spinal anesthesia was
associated with a reduction in the incidence of hypotension per operative without deleterious
effect for the newborn or parturient. In the absence of any observed complications, several
teams began to use noradrenaline prophylactically in other surgery. However, no study has
demonstrated its benefit, particularly the term of surgical complication in abdominal
surgery. The objective of this work is to assess the preventive use of norepinephrine in
major abdominal surgery on the occurrence of intraoperative hypotension, postoperative organ
dysfunction and postoperative medical and surgical complications.