Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia

• Status: Completed
• Trial end date: 2012-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study was to determine if the addition of ketamine reduces remifentanil-induced hyperalgesia, improves its analgesic effect, inhibits IL(interleukin)-6 and IL-8 (inflammatory cytokines), and stimulates IL-10 (an anti-inflammatory cytokine).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Federal University of São Paulo
• Collaborator: Fundação de Amparo à Pesquisa do Estado de São Paulo
• Treatments: Ketamine; Remifentanil

Criteria

Inclusion Criteria:

• ≥ 18 years old

• both sexes

• ASA physical status I or II

• undergoing laparoscopic cholecystectomy

Exclusion Criteria:

• chronic users of analgesics or had used opioids within 12 h of surgery

• history of drug or alcohol abuse or psychiatric disorder

• contraindications to self-administration of opioids (ie, unable to understand the patient-controlled analgesia [PCA] device)

• contraindication for the use of ketamine, such as a psychiatric disorder, acute cardiovascular disorder, or unstable hypertension