Evaluation of the Effect of Sevoflurane and Propofol Hypotensive Anesthesia on Blood Antioxidant Levels and HIF 1 Levels

• Status: Suspended
• Trial end date: 2021-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study to evaluate the patients who underwent controlled hypotensive anesthesia under standardized depth of anesthesia with total intravenous anesthesia or inhalation anesthesia; preoperative and 30. ,60. ,120. second of intraoperative period blood HIF 1a, TAS, TOS measurement and to investigate tissue hypoxia secondary to hypotensive anesthesia and the changes of the mediators at the tissue level and which hypotensive anesthesia technique is related.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bezmialem Vakif University
• Treatments: Anesthetics; Antihypertensive Agents; Antioxidants; Fentanyl; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• 18-55 years old

• ASA Physical Status Classification System 1

• Undergoing to Elective rhinoplasty

Exclusion Criteria:

• Patients have any autoimmune disease

• Smoking of patients

• Development of any allergic reaction during the procedure

• Failure to collect blood to be examined at the appropriate time

• Body mass index is less than 19 or greater than 30

Termination criteria

• Development of severe hypotension and bradycardia during measurements

• Development of severe drug allergy during follow-up

• In the event of any complications related to the surgical procedure