Evaluation of the Effect of Topical Calcipotriol Versus Platelet-Rich Plasma
Status:
Completed
Trial end date:
2023-10-15
Target enrollment:
Participant gender:
Summary
Alopecia areata (AA) is a common, immune-mediated non scarring alopecia and can be associated
with severe psychological consequences . Alopecia Areata affects 2% of the global population.
Alopecia Areata prevalence is lower in adults than children, is increasing over time, and
significantly differs by region.
Its etiology is unknown but it was hypothesized to be an autoimmune disease mediated by
T-lymphocytes. It has been suggested that inflammatory T cells induce growth arrest in hair
bulbs in the anagen phase of the hair cycle . Cytotoxic T cells secrete tumor necrosis
factor, granzymes, and Fas ligand which trigger apoptosis in affected hair follicle and
disrupt hair growth