Evaluation of the Efficacy of Acitretin Therapy for Nail Psoriasis

• Status: Completed
• Trial end date: 2008-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Objective:

Efficacy of systemic retinoid therapy of nail psoriasis has never been assessed objectively. Evaluate therapeutic efficacy of acitretin in patients with isolated nail psoriasis.

Design:

Open-study on thirty-six patients with moderate to severe nail psoriasis treated with acitretin.

Participants:

Patients included 27 men and 9 women (mean age 41) with nail psoriasis. Intervention: Therapy consisted of acitretin 0.2 to 0.3 mg/Kg/day for 6 months.

Main Outcome Measure(s):

Clinical evaluation, NAPSI and modified NAPSI scores before therapy, every 2 months during therapy and 6 months after treatment.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Istituti Fisioterapici Ospitalieri
• Collaborator: University of Bologna
• Treatments: Acitretin

Criteria

Inclusion Criteria:

• patients with moderate to severe nail psoriasis

Exclusion Criteria:

• premenopausal women

• patients with hepatic, renal or metabolic diseases

• patients with skin or symptomatic arthropathic psoriasis

• previous systemic treatment for nail psoriasis