Evaluation of the Efficacy of Azithromycin in Idiopathic Purulent Oedematous Sinusitis in Adults
Status:
Not yet recruiting
Trial end date:
2025-04-01
Target enrollment:
Participant gender:
Summary
Purulent Oedematous Sinusitis (POS) is a particular form of chronic rhinosinusitis observed
in 2% of the general population. In spite of its heavy impact on the quality of life, There
is no established recommendation for the treatment of primary POS. Long-term low-dose
macrolides are currently proposed for these forms of chronic rhinosinusitis when conventional
treatments (local corticosteroids, saline rinsing, iterative short courses of antibiotics
targeted on pathogens, and surgical opening and drainage) have failed. This treatment with
macrolides is currently applied off-label.
This study aims to assess the efficacy of macrolides in POS. An extensive workup is fulfilled
to exclude other forms of chronic rhinosinusitis (Th2 biased inflammatory diseases, allergic
diseases) (allergy, nasosinusal polyposis) or those due to cystic fibrosis or immune
deficiency.