Evaluation of the Efficacy of Probiotics in Chronic Periodontitis Patients
Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
Periodontitis is an infectious inflammatory disease. Bacteria modulate the inflammatory
response and alter the diversity of periodontal disease. In recent years, various
host-response modulation therapies have been developed to block the pathways responsible for
periodontal tissue breakdown.
There have been significant changes with respect to the effectiveness of, and attitudes
towards conventional antimicrobial therapy to combat disease. With the threat of widespread
antibiotic resistance rendering many antibiotics useless against important diseases, there is
an increased necessity not only to minimise antibiotic use and develop novel
non-antibiotic-based treatments, but also to raise the profile of disease prevention. One
approach that has gained interest over recent years is the use of probiotic bacteria for oral
applications. The rationale for their use in oral health care stems from the increase in
evidence that supports their claims for benefit for a range of diseases. Lactobacilli play an
important role in the maintenance of health by stimulating the natural immunity as well as by
contributing to the balance of the microflora, by interacting with the other members of the
flora. The application of health promoting bacteria for therapeutic purposes, is one of the
strongest emerging fields. Time has come to shift the paradigm of the treatment from specific
bacteria elimination to alteration of the bacterial ecology by using probiotics.
So the purpose of this study is to discover a more promising approach for the treatment of
chronic periodontitis .
Phase:
Phase 3
Details
Lead Sponsor:
Next Gen Pharma India Pvt. Ltd.
Collaborators:
K. V. G. DENTAL COLLEGE & HOSPITAL KVG Medical College and Hospital