Evaluation of the Hemodynamic Effect of Dexmedetomidine in Scheduled Outpatient Surgery
Status:
Recruiting
Trial end date:
2025-10-01
Target enrollment:
Participant gender:
Summary
Ambulatory surgery is increasingly used in anesthesia. In case of general anesthesia, it is
recommended to use anesthesia molecules with a short half-life and low doses of opiates to
ensure a rapid awakening and to prevent nausea and vomiting by systematic administration of
anti-emetics during the operation.
Opiates (including sufentanil) have recently been called into question because of the nausea
and vomiting and the delay in waking up induced by these molecules. To combat these side
effects, the authors have proposed either to reduce the doses or to substitute them with
dexmedetomidine, a sedative antihypertensive drug. Recent studies have demonstrated that
opiates used in general anesthesia can be replaced by dexmedetomidine. However, literature
data are controversial concerning the hemodynamic impact. No study has compared the
hemodynamic profile of opioid-free anesthesia with dexmedetomidine versus conventional
anesthesia with opioids.
The ambulatory context lends itself to the use of dexmedetomidine because it is aimed at a
population without strong cardiac pathology, concerns non-major interventions, with the need
to optimize pain and side effects.
The study authors therefore wish to compare the effects of induction of general anesthesia
with low-dose Dexmedetomidine versus sufentanil, on post-induction hemodynamic stability in
scheduled outpatient surgeries. The investigators hypothesize that hemodynamic stability at
induction of general anesthesia with low-dose dexmedetomidine is not inferior to that
obtained with sufentanil in scheduled ambulatory surgeries.