Evaluation of the Inhibitory Effect of 5 Anti-Histamines in Urticaria

• Status: Completed
• Trial end date: 2014-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The antihistamines with inhaled steroids are the cornerstone on the symptomatic therapy in the management of patients with rhinitis and the first line of treatment in patients with urticaria. Currently, the use of antihistamines has become popular due to its excellent safety profile and clinical efficacy, however to the investigators knowledge, there are no studies about the pharmacokinetic and pharmacodynamic effects of these drugs in patients of tropical Latin America. The investigators main interest is to evaluate if skin test inhibition correlates with the clinical effect of five anti-histamines.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Grupo de Alergología Clínica y Experimental
• Treatments: Cetirizine; Desloratadine; Ebastine; Fexofenadine; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine phosphate; Terfenadine

Criteria

Inclusion Criteria:

• Clinical diagnosis of persistent allergic urticaria.

• Age over 12 years and at least one year with the disease

• Informed consent filled.

• Be resident of the metropolitan area of Medellin.

Exclusion Criteria:

• • Use of immunosuppressive drugs