Evaluation of the Use of Indomethacin as Co-treatment in Women With Preterm Labor and High Risk of Intraamniotic Inflammation

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

To demonstrate if indomethacin associated to conventional treatment for preterm labor is useful to delay delivery and to improve neonatal morbimortality in women with preterm labor with high risk of intraamniotic inflammation

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sara Varea
• Treatments: Indomethacin

Criteria

Inclusion Criteria:

• pregnant women with preterm labor admitted to hospital and treated with tocolysis

• pregnant women less than 28.0 and those women from 28.0 to 32.0 with a sonographic cervical length < 15 mm

• single pregnancy

• normal amniotic fluid

• normal arterial ductus

Exclusion Criteria:

• Age below 18 years

• previous use of indomethacin in the index pregnancy

• chorioamnionitis, preterm prelabour rupture of membranes or those fetal or maternal pathologies which could be responsible of an iatrogenic preterm delivery.

• oligohydramnios

• allergy to NSAID

• previous history of gastrointestinal bleeding

• use of NSAID contraindicated

• not adherence to the study