Ex Vivo Expansion of Mafosfamide Purged CD34+ Cells in Patients With Acute Leukemia
Status:
Terminated
Trial end date:
2012-01-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Giving colony-stimulating factors, such as G-CSF, and certain chemotherapy drugs,
helps stem cells move from the bone marrow to the blood so they can be collected. Treating
stem cells collected from the patient's blood or bone marrow with chemotherapy in the
laboratory removes any remaining cancer cells. Chemotherapy or radiation therapy is given to
the patient to prepare the bone marrow for stem cell transplant. The treated stem cells are
then returned to the patient to replace the blood-forming cells that were destroyed by the
chemotherapy.
PURPOSE: This clinical trial is studying how well an autologous peripheral stem cell or bone
marrow transplant using laboratory-treated cells works in treating patients with acute
leukemia.
Phase:
Phase 1
Details
Lead Sponsor:
Sidney Kimmel Comprehensive Cancer Center Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins