Examine the Feasibility of a Standardized Field Test for Marijuana Impairment: Laboratory Evaluations

• Status: Active, not recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Marijuana is one of the most widely used substances. This study will characterize the persistence of cannabis' (CNB's) acute effects on cognitive test performance and simulated driving over a several hour time period. The data obtained from simulated driving, cognitive tests, and biological assays of THC will be used in analyses aimed at identifying what tests or combination of tests predict both recent use and driving impairment risk.

Eligible participants will undergo a full day screening visit, if still eligible they will come to Hartford Hospital in Hartford, Connecticut to take part in the full study. Participation requires overnight stays between each of the five study visits. On each of the study days participants are dosed with either a low dose of THC marijuana, a high dose of THC marijuana or placebo marijuana, (the low and high doses are repeated once each, order in which the study drug is given is double blind and chosen at random.)

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Yale University
• Collaborators: Hartford Hospital; Maastricht University; Montana State University; National Highway Traffic Safety Administration; National Institute on Drug Abuse (NIDA); The Mind Research Network
• Treatments: Dronabinol

Criteria

Inclusion Criteria:

• Must have a current driver's license

• Have used marijuana before

• Right handed

Exclusion Criteria:

• Females who are pregnant or breast feeding

• Any serious medical, or neurological disorder

• Any psychiatric disorder

• No major head traumas