Examining the Effects of Antipsychotic Medications on Insulin Sensitivity

• Status: Completed
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: Male

Summary

This study will examine the effects of two different antipsychotic medications on control of blood sugar in people who are at risk of diabetes but mentally healthy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Veterans Medical Research Foundation
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Antipsychotic Agents; Aripiprazole; Insulin; Olanzapine

Criteria

Inclusion Criteria:

• Prediabetic, defined as 2-hour post-load serum glucose between 140 and 199 mg/dl on a 75-gram standard oral glucose tolerance test (OGTT) within the past 90 days

• Family history of type 2 diabetes mellitus

• Body mass index (BMI) between 25 and 35 kg/m2

• English speaker

• Nonsmoker

Exclusion Criteria:

• History of Axis I mood, anxiety, or psychotic disorder, confirmed by Structured Clinical Interview for DSM-IV

• Use of psychotropic drugs