Exclusive Enteral Nutrition in Patients With Ileocaecal Crohn's Disease
Status:
Recruiting
Trial end date:
2026-01-01
Target enrollment:
Participant gender:
Summary
Inflammatory bowel diseases are chronic and progressive entities, triggered by exposure to
environmental factors in individuals with a genetic background.
One of the most common environmental factors is the type of diet which is a key influencer on
pathogenesis. Nutrients alter the intestinal microbiota, thus changing the intestinal
permeability. The Western-type diet encompasses sugar, fat, and protein-rich products that
have some deleterious effects on the intestinal microbiome compared to the plant-based
Mediterranean-type diet.
Based on this fact, diet-based therapeutic efforts have been used extensively in pediatric
Crohn's disease patients and there is strong evidence that exclusive enteral nutrition (EEN)
is as effective as corticosteroids to induce both clinical and endoscopic remission but this
treatment strategy is underutilized in adults.