Exercise And Rosuvastatin Treatment: Is There an Anti-Inflammatory Synergy?

• Status: Unknown status
• Trial end date: 2007-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether the effects of rosuvastatin treatment and exercise training can be synergistic, with respect to the innate immune receptor TLR4, markers of systemic inflammation, and stimulated production of inflammatory cytokines, in hypercholesterolemic subjects. It is hypothesized that a rosuvastatin and exercise intervention will synergistically lower measured variables, so as to be anti-inflammatory.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Purdue University
• Treatments: Rosuvastatin Calcium

Criteria

Inclusion Criteria:

• Nonfamilial hypercholesterolemia

• Total cholesterol >200 mg/dl, LDL >130 mg/dL

• Physical inactivity

• Moderate to low alcohol intake

Exclusion Criteria:

• Liver or kidney disease

• Acute illness or infection

• Use of corticosteroids, ACE inhibitors, platelet aggregating inhibitors, thiazolidinediones, and bis-phosphonates.

• Use of cyclosporine, warfarin, gemfibrozil or other lipid lowering agents

• Regular antacid or aspirin use

• Type I & II diabetes with insulin treatment

• hypothyroidism, and/or renal insufficiency

• Chronic/debilitating osteoarthritis

• Rheumatoid arthritis

• Central or peripheral nervous system disorders

• Anti-depressant medications

• Major affective disorder

• HIV infection or auto-immune disorders

• Use of tobacco products

• unexplained or intended weight loss of > 2 kg during the previous six months

• Surgery within the previous three months