Exercise Versus DDAVP in Patients With Mild Hemophilia A
Status:
Completed
Trial end date:
2019-12-05
Target enrollment:
Participant gender:
Summary
Individuals with mild hemophilia A (MHA) bleed infrequently but can in the setting of trauma
which often is when participating in sports/exercise. Although both exercise and DDAVP
(desmopressin) can raise Factor 8/Von Willebrand Factor (FVIII/VWF levels), it is not clear
whether the pathophysiological mechanism is the same. Consequently it is not known if DDAVP
and exercise would have additive effects in raising FVIII:C and VWF levels or if one would
one negate the effect of the other. The aim of this 2 center (Sickkids and Nationwide
Children's), prospective, cross-over design study is to compare the impact of exercise vs.
DDAVP on hemostasis in patients with MHA and also to investigate the impact of sequentially
administering these interventions on their hemostatic indices.