Exercise and Metformin in Colorectal and Breast Cancer Survivors
Status:
Completed
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
Metformin is a medication that is commonly used in the treatment of diabetes. Recently small
studies in cancer patients without diabetes suggest that metformin may benefit in lowering
insulin levels. In those studies of patients with cancer but not diabetes, glucose (or sugar)
levels in the blood are generally no lowered. Insulin and insulin-like growth factors affect
the growth of cancer cells.
This randomized study will compare different interventions; exercise, exercise and metformin,
metformin alone, or a control arm. The investigators are not directly testing how either
exercise or metformin affects your disease. The investigators are testing how they affect
insulin levels in your body as well as other blood markers. The investigators believe that
these blood tests may either be related to cancer recurrences or be an early sign of cancer
recurrences and they are testing how both exercise and metformin may change those markers.