Exercise-induced Ischemia and the Influence of Pain Modulation in a Nerve Growth Factor (NGF) Model

• Status: Unknown status
• Trial end date: 2019-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate responses of pain and the maintenance of mechanical muscle hypersensitivity following an acute exercise-induced ischemic condition repeated over time in a prolonged NGF-sensitized muscle. Additionally, the influence of the pain modulating system on prolonged NGF muscle hypersensitivity caused by peripheral mechanisms and central mechanisms will also be investigated.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Aalborg University
• Treatments: Mitogens

Criteria

Inclusion Criteria:

• Healthy and pain free volunteers

Exclusion Criteria:

• Pregnancy

• Drug addiction defined as the use of cannabis, opioids or other drugs

• Previous neurologic, mental illnesses, or psychiatric diseases.

• Past history of chronic pain in the musculoskeletal system (muscle, joint, cartilage, connective tissue)

• Participation in other pain trials throughout the study period

• Lack of ability to cooperate

• Taking any analgesic 24 hours before the injections

• Performing any strenuous leg exercise through out the study period causing sore muscles