The primary purpose is to provide access for patients who have immunodeficiency or severe
autoimmune disease related to poor thymic function to cultured thymus tissue for
implantation. With no thymus function, bone marrow stem cells do not develop into educated T
cells, which fight infection.
Eligible participants receive cultured thymus tissue for implantation and may undergo biopsy.
Immune suppression may be given depending on the immune status and clinical condition of the
participant. Immune function testing is continued for one year post-implantation.