Exploratory Evaluation of the Effect of Cholestyramine on Serum Levels of POPs in Obese Female Patients
Status:
Recruiting
Trial end date:
2025-10-31
Target enrollment:
Participant gender:
Summary
Environmental endocrine disruptors (EDCs) represent a major problem for human health.Some
PEEs can accumulate in the fatty tissue of the human body thanks to their lipophilic nature,
and are known as persistent organic pollutants (POPs).
To assess the benefit of cholestyramine treatment on POPs blood levels in obese patients of
childbearing age undergoing bariatric surgery, in order to reduce their preoperative POPs
load more rapidly. Indeed, the investigators hypothesize that cholestyramine is capable,
outside of acute exposure accidents, of promoting the elimination and release of POPs in the
human population. Given this hypothesis, a treatment administered prior to bariatric surgery
could reduce pre-operative plasma levels of POPs and thus, in fine, minimize the
concentrations reached post-operatively, which are dependent on the release induced by
lipolysis (massive and rapid weight loss) and pre-operative plasma concentrations.