Exploring the Effects of Coenzyme Q10 on Bioenergetics Metabolism in Geriatric Bipolar Depression
Status:
Completed
Trial end date:
2012-07-01
Target enrollment:
Participant gender:
Summary
The investigators propose to study and compare measures of brain energy metabolism in
geriatric bipolar individuals and healthy older adults. The investigators would also like to
investigate changes in brain energy metabolites associated with CoQ10 administration in older
bipolar individuals. Finally, resting state functional Magnetic Resonance Imaging (fMRI) will
be conducted in order to explore frontal and limbic circuitry in geriatric bipolar disorder.
- Primary Hypothesis: Baseline beta NTP and NAA will be lower, and PCr and lactate higher
in Geri BPD compared with older healthy controls
- Secondary Hypothesis: Changes in PCr and beta NTP will be demonstrated in Geri BD group
challenged with CoQ 10.