Exploring the Effects of Diazepam and Lorazepam

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Aims :

• exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI

• comparing lorazepam effects to diazepam (0.3 mg/kg)effects

• exploring benzodiazepines effects, after a single oral intake, on the neural correlates of successful encoding of information within explicit memory using fMRI

Hypothesis :

• both diazepam and lorazepam will impair explicit memory performance, but lorazepam only will impair perceptual priming

• lorazepam and diazepam will modify the normal correlates of information encoding within explicit memory

• lorazepam only will alter the neural correlates of perceptual priming

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Strasbourg, France
• Treatments: Diazepam; Lorazepam

Criteria

Inclusion Criteria:

• Healthy subjects between 18 and 30 years

• Students in medicine, dentistry or pharmacy

• French as a mother language

Exclusion criteria:

• Medical condition influencing brain function (neurological or psychiatric)

• Asthma

• General anesthesia in the 3 last months

• Drug addiction (DSM IV criteria)

• Regular medical treatment (except contraceptive pill)

• Significant impairment observed during a medical examination including ECG

• Intake of any psychotropic drug that can have a effect during testing

• IQ (Wechsler) < 100

• FMRI contra-indication (implantable magnetic material, claustrophobia)

• Known allergy to benzodiazepine or lactose

• > 10 cigarettes/day

• Pregnant or breast-feeding woman

• No health insurance

• Subjects who do not complete the entire study