Exploring the Safety and Efficacy of Low-dose Ketamine Infusions for Pain Control in Acute Burn Injury

• Status: Withdrawn
• Trial end date: 2018-05-24
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to identify the optimal dosing strategy for low-dose ketamine infusions in adult acute burn injury patients when used with usual pain medications.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Kansas Medical Center
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• Acute burn injury comprising 10-30% of total body surface. Burns severity may include second or third degree burns

• Burn injury must have occurred within 72 hours of enrollment and randomization

• Subjects may be opioid-naïve or opioid non-naïve

• Anticipated stay in the burn unit is greater than 4 days, which is typically the minimum length of stay for patients with this level of burn injury

Exclusion Criteria:

• Burn injury older than 72 hours

• Acute burn injury comprising >30% total body surface

• Patients who are intubated

• Patients who have contraindication to ketamine administration