Exposure of Salvaged Blood to Inflammation and Oxidative Stress: the Effect of Different Anticoagulant Regimes (HECICS)

• Status: Completed
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary aim of this randomized controlled study is to determine whether the use Anticoagulant Citrate Dextrose Solution--Formula A (ACD-A) in cell salvage reduces inflammation and oxidative stress in cell saver blood compared to heparin. The secondary aim is to determine whether any differences in activation can be correlated to any differences in postoperative clinical outcome.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ziekenhuis Oost-Limburg
• Treatments: Anticoagulants; Calcium heparin; Citric Acid; Heparin; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

Elective cardiac revascularization surgery patients: subgroup analysis for

• on pump coronary artery bypass grafting (CABG)

• off pump CABG (OPCABG)

Exclusion Criteria:

• Urgent procedures

• Severe shock

• Active infection

• Inflammatory diseases

• Active neoplasia

• Immune suppressive drugs

• Active or recent renal replacement therapy (RRT)

• Anticoagulation or anti-aggregation therapy that hasn't been timely interrupted according to guidelines (12,13)

• Need for allogenous blood transfusion before completion of data collection

• Massive peroperative bleeding that cannot be safely managed while collecting study data