Extended Infant Post-exposure Prophylaxis With Antiretrovirals to Reduce Postnatal HIV Transmission

• Status: Completed
• Trial end date: 2009-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if extended antiretroviral regimens given to the infant during the first 14 weeks of age would decrease breast milk transmission of HIV.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Johns Hopkins Bloomberg School of Public Health
• Collaborators: Centers for Disease Control and Prevention; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
• Treatments: Nevirapine; Zidovudine

Criteria

Inclusion Criteria:

• Had given birth within the last 24 hours

• Ability and willingness to give informed consent for HIV testing and enrollment into the study

• Willing to receive HIV results

• HIV infected

• Planning to deliver or had given birth at the study clinics

• Willing to come back for follow-up visits for 2 years postnatally

• Resident of Blantyre city or its suburbs

Exclusion Criteria:

• HIV negative

• Women with discordant HIV results

• Women who indicate that they will not breastfeed at time of delivery

• Inability or unwillingness to follow any of the inclusion requirements

• Newborn with life-threatening condition

• Women who previously enrolled in this study and have a second pregnancy cannot reenroll