Extended-Release Tacrolimus Following Liver Transplantation
Status:
Not yet recruiting
Trial end date:
2033-02-15
Target enrollment:
Participant gender:
Summary
Medications used after transplant to prevent rejection are associated with many side effects.
Tacrolimus side effects include kidney dysfunction; tremor, headaches, difficulty sleeping,
change in sensation (legs), seizure, or confusion; high blood pressure; anemia, or low blood
cell counts; diabetes; abnormal cholesterol and weight gain. The investigators want to use a
new, approved, formulation of the standard medication (Envarsus) as they believe it may be
associated with reduced side effects. The investigators would like to assess how safe it is
to use this medication and how well it works in comparison to currently used formulations.
The investigators will study if there are less side effects and will study clinical outcomes
(including how well the liver does and if there is need for hospitalizations after
transplant).
The investigators hope that this information will improve the care provided to and outcomes
in patients following liver transplant.