Extracellular Fluid in Resistant Hypertension

• Status: Terminated
• Trial end date: 2006-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The optimal treatment of drug resistant (defined as BP> 140/85 despite three anti-hypertensive drugs including a diuretic) is not well defined. This study aims to test the hypothesis that resistant hypertension is caused by excessive expansion of extracellular fluid volume. A secondary objective is to study which of three different antihypertensive drugs would be most useful in drug resistant hypertension.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: St George's, University of London
• Treatments: Amiloride; Furosemide

Criteria

Inclusion Criteria:

• BP >140/85

• 3 antihypertensive drugs (ACE/ARB + calcium channel blocker + thiazide diuretic)

Exclusion Criteria:

• Pregnancy

• Breast Feeding

• Unstable heart failure

• Chronic Liver Disease

• Creatinine >120 mcmol/L

• Contraindication to (or intolerance of) drug used in study

• BP > 180/110