F 18 T807 PET (Positron Emission Tomograph )Scan for HIV Infected & Uninfected
Status:
Completed
Trial end date:
2018-05-23
Target enrollment:
Participant gender:
Summary
This project will collect quantitative pilot data that will allow the characterization of
uptake and binding of 18F-AV-1451 (also known as F 18 T807, also known as T807, also known as
7-(6-fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole), a novel tau imaging compound, in older HIV+
individuals with and without HAND and matched HIV uninfected (HIV-) controls. The primary
goal is to develop this highly promising tau imaging technique as an biomarker of cognitive
decline in HIV+ individuals. The investigators will obtain preliminary data that will support
the possibility of detecting early brain pathological changes due to HIV. Data generated from
this study will be used for submission of National Institutes of Health (NIH) grants
comparing tau deposition in HAND compared to other neurodegenerative disorders. It is
hypothesized that specific topographies will help distinguish these neurodegenerative
disorders in older individuals.
Details
Lead Sponsor:
Tammie L. S. Benzinger, MD, PhD Washington University School of Medicine