Overview

F 18 T807 Tau PET Imaging of Alzheimer's Disease

Status:
Recruiting
Trial end date:
2024-12-01
Target enrollment:
0
Participant gender:
All
Summary
This project will collect quantitative pilot data that will allow the characterization of uptake and binding of 18F-AV-1451 (also known as F 18 T807), a novel tau imaging compound, in individuals with and without brain tau fibrils. The primary goal is to develop tau imaging technique as an antecedent biomarker of cognitive decline. The investigators propose to obtain preliminary data that will support the possibility of detecting cognitive decline in its earliest stages, before the occurrence of dementia.
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Tammie L. S. Benzinger, MD, PhD
Washington University School of Medicine
Criteria
Inclusion Criteria:

1. Male or female participants, at least 18 years of age.

2. Cognitively normal, or with mild dementia, as assessed clinically

3. Participant is able and willing to undergo testing (MRI or CT, PET, radioactive tracer
injection, LP; for those unable to undergo an MRI, CT will be used to generate
regions-of-interest).

4. Pre-menopausal women will undergo a urine pregnancy test within 24 hours of drug
administration.

Exclusion Criteria:

1. Has any condition that, in the Investigator's opinion, could increase risk to the
participant, limit the participant's ability to tolerate the experimental procedures,
or interfere with the collection/analysis of the data (for example, participants with
severe chronic back pain might not be able to lie still during the scanning
procedures).

2. Is deemed likely unable to perform the imaging procedures for any reason.

3. Has a high risk for Torsades de Pointes or is taking medications known to prolong QT
interval.

4. Has hypersensitivity to F 18 T807 or any of its excipients.

5. Contraindications to PET, PET-CT or MR (e.g. electronic medical devices, inability to
lie still for long periods) that make it unsafe for the individual to participate.

6. Severe claustrophobia.

7. Currently pregnant or breast-feeding.

8. For those electing to undergo the optional lumbar puncture: currently on anticoagulant
of any form -