This study is a double-blind, placebo controlled, series of N-of-1 trials of individualised
stimulant dose on ADHD symptomatology in children with FASD.
The broad aim of this study is to contribute new evidence towards understanding treatment
efficacy for ADHD symptoms in FASD.
Specific aims are:
1. To assess the ongoing effectiveness of stimulant medication prescribed for ADHD symptoms
in individual children with FASD of clinically prescribed stimulant medication compared
to placebo to control ADHD symptoms (using behavioural and cognitive measures) in
children with FASD and ADHD using a N-of-1 trial design.
2. To obtain pilot data to examine feasibility and tolerability of the planned N-of-1 trial
design in children with FASD and ADHD for future and larger studies that might seek to
examine if the different stimulant types are equally effective relative to placebo.
3. To review the multiple N-of-1 data to analyze key individual factors that mediate the
effect of stimulants relative to placebo on ADHD symptoms, including underlying child
factors (attention skills, cognitive function), sociodemographic factors and other
prenatal exposures.