FAU in Treating Patients With Advanced Solid Tumors or Lymphoma

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Drugs used in chemotherapy, such as FAU, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. This phase I trial is studying the side effects and best dose of FAU in treating patients with advanced solid tumors or lymphoma.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Cancer Institute (NCI)
• Treatments: 2'-fluoro-5-ethylarabinosyluracil; Deoxyuridine

Criteria

Inclusion Criteria:

• Measurable disease by CT scan and/or MRI

• Archival tumor tissue sample available for correlative pharmacodynamic and pharmacogenomic studies

• Accessible tumor tissue available (for patients enrolled in the expanded maximum tolerated dose [MTD] cohort)

• No known active brain metastases but previously treated brain metastases allowed

• ECOG performance status (PS) 0-1 OR Karnofsky PS 70-100%

• AST and ALT =< 2.5 times upper limit of normal (ULN) (=< 5 times ULN if liver metastases are present)

• Alkaline phosphatase =< 2.0 times ULN (=< 5 times ULN if bone or liver metastases are present)

• Bilirubin normal

• Creatinine normal or creatinine clearance >= 60 mL/min

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• Willing to undergo tumor biopsies for correlative pharmacodynamic studies (for patients enrolled in the expanded MTD cohort)

• Able to lie still for PET scan

• Weight =< 300 lbs

• No uncontrolled illness including, but not limited to, any of the following:

• Ongoing or active infection

• Symptomatic congestive heart failure

• Unstable angina pectoris

• Cardiac arrhythmia

• Psychiatric illness/social situation that would preclude compliance with study requirements

• No history of allergic reactions attributed to compounds of similar chemical or biologic composition to FAU

• More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas, mitomycin C, or bleomycin), immunotherapy, or experimental therapy and recovered

• More than 4 weeks since prior radiotherapy to > 5% of total marrow volume

• No prior radiotherapy to >= 50% of total marrow volume

• More than 3 weeks since prior radiotherapy to =< 5% of total marrow volume

• No other concurrent investigational agents

• ANC >= 1,500/mm^3

• Platelet count >= 100,000/mm^3

• Life expectancy > 12 weeks

• Histologically or cytologically confirmed malignant solid tumor for which standard curative or palliative measures do not exist or are no longer effective

• Solid hematologic malignancies (e.g., Hodgkin or non-Hodgkin lymphoma) allowed provided bone marrow biopsy has been performed within the past 6 weeks

• Metastatic or unresectable disease

• No other concurrent anticancer therapy (e.g., cytotoxic therapy, biologic therapy, radiotherapy, or hormonal therapy)

• Concurrent hormone replacement therapy allowed

• Concurrent megestrol acetate or bisphosphonates allowed provided they were started 1 month prior to study enrollment

• Concurrent luteinizing hormone-releasing hormone agonists to maintain castrate levels of testosterone allowed for patients with prostate cancer