FFA-Induced Hypertension and Endothelial Dysfunction

• Status: Completed
• Trial end date: 2008-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The study is a prospective open label study to examine the effects of oral and intravenous fat load on blood pressure, endothelial function, sympathetic activity, and oxidative stress in obese healthy subjects. Subjects will receive either 8-hour of intravenous or oral fat loads in either low or high doses or normal saline in random order. Blood samples are drawn and vitals are measured before and after the infusions. Endothelial function and plasma glucose and lipid levels are measured to study the effects.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Emory University
• Collaborator: American Heart Association
• Treatments: Soybean oil, phospholipid emulsion

Criteria

Inclusion Criteria:

• Males or females between the ages of 18 and 65 years.

• Definition: obese = BMI ≥ 30 kg/m2

• Blood pressure < 140/80 mm Hg and no prior history of hypertension

Exclusion Criteria:

• History of hypertension or previous history of antihypertensive drug therapy.

• Current tobacco use

• Fasting triglyceride levels > 250 mg/dL during the stabilization period.

• Liver disease (ALT 2.5x > upper limit of normal), or other significant medical or surgical illness, including myocardial ischemia, congestive heart failure, liver failure, and infectious processes.

• Serum creatinine ≥1.5 mg/dL for males, or ≥ 1.4 mg/dL for females.

• History of drug or alcohol abuse within the last 5 years.

• Mental condition rendering the subject unable to understand the nature, scope, and possible consequences of the study.

• Female subjects are pregnant or breast feeding at time of enrollment into the study.