FGF-23 (Fibroblast Growth Factor 23) Regulation in Chronic Kidney Disease
Status:
Completed
Trial end date:
2015-06-01
Target enrollment:
Participant gender:
Summary
FGF-23 is a newly described protein that is an important regulator of phosphorus in the body.
This protein increases in people with kidney disease and people who need dialysis have very
high levels of FGF-23 in the blood. However, although some studies have indicated that FGF-23
levels go up with increased intake of phosphorus, no one knows if FGF-23 levels can be
lowered in patients with kidney disease by preventing them from absorbing phosphorus from
food. This study is designed to see what happens to levels of FGF-23 in the blood when
patients with chronic kidney disease take medications to prevent phosphorus absorption. Since
high levels of FGF-23 have been linked with increased rates of death in patients with
advanced kidney disease, controlling the levels may, in the future, be a way to decrease
heart disease in patients with kidney disease.