Overview

FIH XON7 in Advanced/Metastatic Solid Tumors

Status:
Recruiting
Trial end date:
2027-11-01
Target enrollment:
0
Participant gender:
All
Summary
This is a two-stage trial consisting of a Part I, dose escalation and dose-finding component to establish the Maximal Tolerated Dose (MTD), if any, and Recommended Part 2 Dose (RP2D) of XON7, followed by a Part II component to investigate anti-tumors efficacy in selected solid tumor types and to further evaluate safety and tolerability of XON7 at RP2D.
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Xenothera SAS
Criteria
Inclusion Criteria:

1. Provide signed, written informed consent.

2. Male and female participant, age ≥ 18 years old (at the time consent is obtained)

3. Solid tumors indications:

- Participant in phase I, must have a histologically or cytologically confirmed
advanced or metastatic solid tumors for which no effective standard therapy is
available. All tumor types except glioblastoma, could be included.

- Participant in phase II, must have histologically or cytologically confirmed
advanced or metastatic solid tumors of the following: NSCLC, gastro-esophageal
adenocarcinoma, CRC, pancreatic cancer, Sarcoma, TNBC, or ovarian cancer.

4. Line of treatment: Participant must have solid tumors progressing after ≤ 4 lines of
standard appropriate anticancer therapies for the specific tumor type, or for which
the patient is ineligible. Participants whose cancers harbor molecular alterations for
which targeted therapy is standard of care should have received health
authority-approved appropriate targeted therapy for their tumor types before
enrollment.

5. Measurable disease per RECIST version 1.1 - v5

6. (ECOG) performance status (PS) 0-1

7. Life expectancy of at least 12 weeks.

8. Adequate organ function

9. QT duration corrected for heart rate by Fridericia's formula (QTcF) <450 msec or QTcF
<480 msec for participants with bundle branch block.

10. In France, a participant will be eligible for inclusion in this trial only if either
affiliated to or a beneficiary of a social security category.

11. Female participant who are not of child-bearing potential, and female participants of
child-bearing potential who have a negative serum pregnancy test within 7 days prior
to initial trial treatment. Female participants of child-bearing potential, and all
male partners must consent to use a medically acceptable method of contraception
throughout the trial period and for at least 60 days after the last dose of XON7. A
barrier method of contraception must be included.

12. Male participant willing to use adequate contraceptive measures throughout the trial
period and for at least 60 days after the last dose of trial intervention.

13. For phase II, participant in pharmacodynamics cohort must provide biopsy of a tumor
lesion not previously irradiated during the screening period and must agree to provide
at least one additional on-treatment biopsy between day 36 and 42 after trial
intervention administration.

14. For phase II, participant in pharmacodynamics cohort must have accessible tumor tissue
available for fresh biopsy except for ovarian cancer and sarcoma.

Exclusion Criteria:

1. A participant who has received more than 4 prior lines of therapy for advanced or
metastatic disease.

2. A participant who has had a prior anti-cancer mAb within 3 weeks prior to trial Day 1
or who has not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events due to
agents administered more than 4 weeks earlier prior to trial Day 1.

3. A participant who has had prior chemotherapy, targeted small molecule therapy, or
radiation therapy within 2 weeks prior to trial Day 1 or who have not recovered (i.e.,
≤ Grade 1 or at baseline) from adverse events due to a previously administered agent
(Except alopecia, hearing loss, grade 2 neuropathy or endocrinopathy managed with
replacement therapy).

4. A participant with ≥Grade 3 toxicity related to prior immunotherapy leading to
treatment discontinuation.

5. A participant whose toxicity related to prior treatment has not resolved to Grade 1
(except alopecia, hearing loss, grade 2 neuropathy or endocrinopathy managed with
replacement therapy).

6. A participant who has received major surgery 2 weeks before the first dose of trial
treatment or has not recovered adequately from the toxicity and/or complications from
any surgery (major or minor) before initiating trial treatment.

7. Concomitant use of another experimental drug, or wash-out period of at least 5
half-lives for a previous experimental drug not completed before start of trial
intervention

8. Participant treated with drugs known to prolong the QT interval

9. Participant with carcinomatous meningitis.

10. Central nervous system (CNS) metastases, with the exception of individuals who have
been previously treated CNS metastases, are asymptomatic, and have had no requirement
for steroids for 3 weeks prior to first dose of trial drug.

11. Malignancies other than disease under trial within 3 years prior to first dose of
trial intervention.

12. History of autoimmune disease

13. Active or uncontrolled infections requiring systemic treatment (known human
immunodeficiency virus infection, or positive test for hepatitis B surface antigen or
hepatitis C).

14. Any severe and/or uncontrolled medical conditions or other conditions that could
affect their participation in the trial such as history or evidence of cardiovascular
risk including any of the following:

- Recent (within the past 6 months) history of serious uncontrolled cardiac
arrhythmia or clinically significant ECG abnormalities including second degree
(Type II) or third-degree atrioventricular block.

- Documented cardiomyopathy, myocardial infarction, acute coronary syndromes
(including unstable angina pectoris), coronary angioplasty, stenting, or bypass
grafting within the past 6 months before enrollment.

- Documented congestive heart failure (Class II, III, or IV) as defined by the New
York Heart Association functional classification system (NYHA, 1994).

15. Prior allogeneic or autologous bone marrow transplantation or other solid organ
transplantation.

16. Current active liver or biliary disease (Except for Gilbert's syndrome or asymptomatic
gallstones, liver metastases, or otherwise stable chronic liver disease per
investigator assessment).

17. Concurrent medical condition requiring the use of systemic immunosuppressive
medications within 28 days before the first dose of trial treatment.

18. Recent history (within the past 6 months) of acute diverticulitis, inflammatory bowel
disease, intra-abdominal abscess, or gastrointestinal obstruction.

19. Current or history of idiopathic pulmonary fibrosis, interstitial lung disease, or
organizing pneumonia. Note: post-radiation changes in the lung related to prior
radiotherapy and/or asymptomatic radiation-induced pneumonitis not requiring treatment
may be permitted if agreed by the investigator and Medical Monitor.

20. History of (non-infectious) pneumonitis that required steroids or current pneumonitis.

21. Recent history (within 6 months) of uncontrolled symptomatic ascites or pleural
effusions.

22. Participant who has received transfusion of blood products (including platelets or red
blood cells) or administration of colony stimulating factors (including granulocyte
colony- stimulating factor [G-CSF], granulocyte-macrophage colony-stimulating factor
[GM- CSF], recombinant erythropoietin) within 2 weeks before the first dose of trial
intervention.

23. Known, current drug or alcohol abuse.

24. Female participant who is pregnant or lactating.

25. Psychological, familial, sociological, or geographical conditions that do not permit
compliance with the protocol.

26. Inability or unwillingness to comply with trial and/or follow-up procedures outlined
in the protocol.

27. For France, patients under legal protection (safeguard, guardianship, curatorship)