FMISO PET/CT Imaging Trial for Assessing Hypoxia in Soft Tissue Sarcomas
Status:
Terminated
Trial end date:
2021-02-18
Target enrollment:
Participant gender:
Summary
Subjects with known or suspected primary soft tissue sarcoma of the extremities may be
eligible for this study. Subjects may participate in this study if they are at least 18 years
of age. Most participants will be receiving care at the clinical practices of the University
of Pennsylvania Health System.
Positron emission tomography (PET/CT) imaging will be used to evaluate soft tissue sarcoma
hypoxia using an investigational radiotracer, 18F-FMISO Subjects will also undergo an 18F-FDG
PET/CT scan close to the time of their initial hypoxia PET/CT to compare in vivo measures of
hypoxia to 18F-FDG uptake. The FDG PET/CT may be performed as part of standard clinical care
or as a research scan. Both PET/CT scans will occur prior to starting new therapy.