Overview
FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder
Status:
Completed
Completed
Trial end date:
2012-11-01
2012-11-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
This study will assess the effects of bipolar disorder on brain activity and will determine if medication changes the brain activity in people with bipolar disorder.Phase:
Phase 4Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Indiana UniversityCollaborator:
National Institute of Mental Health (NIMH)Treatments:
Lithium Carbonate
Criteria
Inclusion criteria for BD participants:- Meets DSM-IV criteria for bipolar I or II disorder
- Meets criteria to undergo an MRI scan based on MRI screening questionnaire
- Suited for outpatient care during the study as ascertained by a score of less than 5
on the Clinical Global Severity Scale, no significant suicidal or homicidal ideation,
and no severe disability
Inclusion criteria for BD depressed participants:
- Meets criteria for DSM-IV depressive episode-current
- Score of greater than 15 but less than 30 on the 17-item HDRS
- Score of less than 12 on the Young Mania Rating Scale
Inclusion criteria for BD (hypo) manic participants:
- Meets criteria for DSM-IV manic episode-current
- Score of less than or equal to 18 on the 17-item HDRS
- Score of greater than 12 but less than 25 on the Young Mania Rating Scale
Inclusion criteria for BD euthymic patients:
- Satisfy criteria for DSM-IV for euthymic state-current for at least 2 weeks.
- 17-item Hamilton Depression Rating Scale < 12; Young Mania Rating Scale score < 10
Exclusion criteria for BD participants:
- Meets DSM-IV criteria for unipolar depression, schizophrenia, schizophreniform
disorder, schizoaffective disorder, atypical psychosis, anxiety disorder as a primary
diagnosis, mental retardation, or personality disorder
- Received electroconvulsive therapy in the 12 months prior to study entry
- Use of neuroleptics, mood stabilizers, or benzodiazepines in the 2 weeks prior to
study entry
- Use of antidepressants in the 2 weeks prior to study entry
- Use of fluoxetine in the 5 weeks prior to study entry
- Use of lithium in the 6 months prior to study entry
- Acutely suicidal or homicidal or requiring inpatient treatment
- Meets DSM-IV criteria for substance/alcohol dependence, excluding caffeine or
nicotine, in the 6 months prior to study entry or substance/alcohol abuse in the 3
months prior to study entry
- Use of alcohol in the 1 week prior to study entry and refusal to avoid alcohol use
during the course of the study
- Presence of serious acute or chronic medical or neurological illness, including
previously known HIV positive status (due to possible CNS involvement) as assessed by
history, physical examination, and laboratory examination
- Pregnant or breastfeeding
- Metallic implants or other contraindication to MRI
Inclusion criteria for first degree relatives of bipolar disorder subjects:
- Ages 15-60 years (inclusive) and able to give voluntary informed consent.
- Have never satisfied criteria for DSM-IV BD.
- Satisfy criteria to undergo an MRI scan based on MRI screening questionnaire.
- 17-item Hamilton Depression Rating Scale < 10; Young Mania Rating Scale score < 10
Exclusion criteria for first degree relatives of bipolar disorder subjects:
- Under 15 years of age.
- Meeting DSM-IV criteria for current episode of unipolar depression
- Pregnant or breast feeding.
- Metallic implants or other contraindication to MRI.
- Currently taking any prescription or centrally acting medications.
- Serious acute or chronic medical or neurological illness as assessed by history,
physical examination and laboratory examination including CBC and blood chemistry.
- Use of alcohol in the past 1 week and not being able to avoid alcohol use during the
course of the study.
Inclusion criteria for healthy subjects:
- Ages 18-60 years (inclusive) and able to give voluntary informed consent.
- No current or past history of psychiatric illness or substance abuse or dependence.
- No current or past history of psychiatric illness or substance abuse or dependence in
a first degree relative.
Exclusion criteria for healthy participants:
- Under 18 years of age
- Pregnant or breastfeeding
- Metallic implants or other contraindication to MRI
- Significant family history of psychiatric or neurological illness
- Currently taking any prescription or centrally acting medications
- Serious acute or chronic medical or neurological illness as assessed by history,
physical examination, and laboratory examination
- Use of alcohol in the 1 week prior to study entry and refusal to avoid alcohol use
during the course of the study