FOLFOX Followed by FOLFIRI or Reverse Sequence Treatment in Advanced Gastric Cancer (AGC)
Status:
Completed
Trial end date:
2013-09-01
Target enrollment:
Participant gender:
Summary
FOLFOX* followed by FOLFIRI** or reverse sequence treatment regimen have been used as a
standard treatment modality in metastatic colorectal cancer.Oxaliplatin and Irinotecan were
used for advanced gastric cancer also. The investigators study was designed to evaluate the
safety and efficacy of FOLFOX followed by FOLFIRI or reverse sequence treatment regimen as a
first-line and second line therapy for patients with relapsed or metastatic gastric cancer
similar with colorectal cancer.
*FOLFOX: oxaliplatin followed by leucovorin before bolus 5-FU followed by continuous infusion
5-FU
**FOLFIRI: irinotecan followed by leucovorin before bolus 5-FU followed by continuous
infusion 5-FU